Airway epithelial cells: ‘Bicarbonate in’≠‘Bicarbonate out’
نویسندگان
چکیده
منابع مشابه
Bicarbonate and Chloride Secretion in Calu-3 Human Airway Epithelial Cells
Serous cells are the predominant site of cystic fibrosis transmembrane conductance regulator expression in the airways, and they make a significant contribution to the volume, composition, and consistency of the submucosal gland secretions. We have employed the human airway serous cell line Calu-3 as a model system to investigate the mechanisms of serous cell anion secretion. Forskolin-stimulat...
متن کاملEvidence that Calu-3 human airway cells secrete bicarbonate.
The Calu-3 cell line is being investigated as a model for human submucosal gland serous cells. In a previous investigation of basal short-circuit current ( I sc) in Calu-3 cells, high levels of bumetanide-insensitive basal I sc (∼60 μA/cm2) were measured in cells grown at an air interface. Basal I sc was reduced only 7% by bumetanide, and the largest component of basal I sc required both Cl- an...
متن کاملEpithelial cells, Exracellular matrix
چکیده مقدمه: ماده خارج سلولی به عنوان بخش مهم ریز محیطMicroenvironment)(، نقش اساسی در نگهداری وضعیت تمایز دارد. در بررسی‌های گذشته، این اثر در برخی سلول‌ها از جمله سلول‌های پوششی لوله رحم و یا رحم مطالعه شده است. در این پژوهش‌ها، برای حفظ تمایز سلول ، علاوه بر ماده خارج سلولی عوامل دیگر‌ی مانند هورمون‌ها، فاکتورهای رشد و سلول‌های داربستی نیز بکار رفته است ولی فر...
متن کاملRhinovirus C targets ciliated airway epithelial cells
BACKGROUND The Rhinovirus C (RV-C), first identified in 2006, produce high symptom burdens in children and asthmatics, however, their primary target host cell in the airways remains unknown. Our primary hypotheses were that RV-C target ciliated airway epithelial cells (AECs), and that cell specificity is determined by restricted and high expression of the only known RV-C cell-entry factor, cadh...
متن کاملAccessory cell function of airway epithelial cells.
Accessory cell function of airway epithelial cells. We previously demonstrated that airway epithelial cells (AECs) have many features of accessory cells, including expression of class II molecules CD80 and CD86 and functional Fcgamma receptors. We have extended these studies to show that freshly isolated AECs have mRNA for cathepsins S, V, and H [proteases important in antigen (Ag) presentation...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2012
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2012.242586